10, No. The syndrome of “Gadolinium Deposition Disease” was discussed, along with future areas for research and clinical management. 1, 1 March 2016 | Japanese Journal of Radiology, Vol. 139, No. 5, 29 November 2018 | Journal of Medical Toxicology, Vol. 3, 27 September 2016 | Multiple Sclerosis Journal, Vol. * GBM = glioblastoma multiforme, ICH = intracranial hemorrhage, TBI = traumatic brain injury, TIA = transient ischemic attack. 48, No. 1, 21 September 2017 | Physiological Measurement, Vol. 2, 11 August 2016 | Radiology, Vol. 33, No. 48, No. 26, No. Suivi en imagerie par résonance magnétique des patients avec une sclérose en plaques : comment ? 8, The International Journal of Cardiovascular Imaging, Vol. Does renal function affect gadolinium deposition in the brain? T1 Magnetic Resonance Imaging Contrast in a Compact Plasmonic Nanoparticle with Enhanced Fluorescence, Gadolinium Deposition in Deep Brain Structures: Relationship with Dose and Ionization of Linear Gadolinium-Based Contrast Agents, Chemical exchange-sensitive spin-lock (CESL) MRI of glucose and analogs in brain tumors, The use of gadolinium-based contrast agents in Ghana with a focus on residual intracranial gadolinium deposition, Evaluation of an equilibrium phase free-breathing dynamic contrast-enhanced MRI prototype sequence compared to traditional breath-held MRI acquisition in liver oncology patients, The effect of gadolinium-based contrast agents on rat testis, Accumulation of Gadolinium in Human Cerebrospinal Fluid after Gadobutrol-enhanced MR Imaging: A Prospective Observational Cohort Study. Intravenous GBCA was never withheld from a patient in this group because of concern for acute or stage 4 or 5 chronic renal failure (eGFR < 30 mL/min/1.73 m2). OBJECTIVE: The aim of this study was to assess gadolinium deposition in the skin of a patient with normal renal function, based on estimated glomerular filtration rate values greater than 59 mL/min/1.73 m(2) after exposure to large cumulative doses of gadolinium-based contrast agents (GBCAs). 6, Angewandte Chemie International Edition, Vol. 3, American Journal of Otolaryngology, Vol. Deposition of gadolinium in the brain has been increasingly reported in recent years. Increased T1 signal may be seen in the basal gangia and dentate nuclei of patients receiving multiple gadolinium injections secondary to gadolinium accumulation. 47, No. It remains possible that bone matrix may rapidly take up a small fraction of intravenously administered GBCA and act as a reservoir, slowly releasing gadolinium with subsequent uptake in other tissues. In contradistinction to bone and other tissues, where gadolinium deposition can be explained by the presence of fenestrated capillary systems, our findings suggest that gadolinium from administered GBCA is able to cross an otherwise intact blood-brain barrier and that compromise of this barrier is not necessary for tissue deposition. 10, Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 52, Magnetic Resonance in Medicine, Vol. Renal function was assessed before each MR examination to screen for chronic renal failure by using estimated glomerular filtration rate (eGFR) derived from serum creatinine results collected within 24 hours of MR imaging (17). 275, No. 1, American Journal of Physiology-Renal Physiology, Vol. 2019, No. : Quantitative analysis of T1 shortening using R1 relaxometry in glioblastoma multiforme patients, Efficacy of double inversion recovery magnetic resonance imaging for the evaluation of the synovium in the femoro-patellar joint without contrast enhancement, Super-resolution intracranial quiescent interval slice-selective magnetic resonance angiography, Ferumoxytol Is Not Retained in Kidney Allografts in Patients Undergoing Acute Rejection, Effects of serial macrocyclic-based contrast materials gadoterate meglumine and gadobutrol administrations on gadolinium-related dentate nuclei signal increases in unenhanced T1-weighted brain: a retrospective study in 158 multiple sclerosis (MS) patients, Imaging Human Brain Perfusion with Inhaled Hyperpolarized 129Xe MR Imaging, Choosing the Safest Gadolinium-based Contrast Medium for MR Imaging: Not So Simple after All, Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss, Non-clinical assessment of safety and gadolinium deposition after cumulative administration of gadobenate dimeglumine (MultiHance ® ) to neonatal and juvenile rats, Comparison of Unenhanced T1-Weighted Signal Intensities Within the Dentate Nucleus and the Globus Pallidus After Serial Applications of Gadopentetate Dimeglumine Versus Gadobutrol in a Pediatric Population, Characterization of a hepatic haemangioma with contrast-enhanced ultrasound in an infant, Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: a clinical tool for studying tumour metabolism, Evaluation of Gadolinium Retention After Serial Administrations of a Macrocyclic Gadolinium-Based Contrast Agent (Gadobutrol), Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure, Nano-confinement-driven enhanced magnetic relaxivity of SPIONs for targeted tumor bioimaging, MRI surveillance of vestibular schwannomas without contrast enhancement: Clinical and economic evaluation, Ionizing radiation from computed tomography versus anesthesia for magnetic resonance imaging in infants and children: patient safety considerations, The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging, Gadolinium depositions after the application of the hepatospecific gadolinium-based contrast agent gadoxetate disodium, Toxic-induced cerebellar syndrome: from the fetal period to the elderly, Deep Brain Nuclei T1 Shortening after Gadobenate Dimeglumine in Children: Influence of Radiation and Chemotherapy, Imaging in Renal Failure, Neonatal Oligoanuria, and Renal Transplantation, Gadolinium-Based Contrast Agents in Kidney Disease: A Comprehensive Review and Clinical Practice Guideline Issued by the Canadian Association of Radiologists, An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging, Single-Shot Coronary Quiescent-Interval Slice-Selective Magnetic Resonance Angiography Using Compressed Sensing, Physics and Practical Considerations of CEDM, Intravoxel incoherent motion (IVIM) and non-Gaussian diffusion MRI of the lactating breast, Assessment of regional pulmonary blood flow using 68Ga-DOTA PET, Non-caloric sweetener provides magnetic resonance imaging contrast for cancer detection, Synthesis of europium-doped VSOP, customized enhancer solution and improved microscopy fluorescence methodology for unambiguous histological detection, Non-contrast MR angiography at 1.5 Tesla for aortic monitoring in Marfan patients after aortic root surgery, Saccular measurements in routine MRI can predict hydrops in Menière’s disease, High-throughput gadobutrol-enhanced CMR: a time and dose optimization study. 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